Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 12/20 | 0.74 |
| ▸ | PRKCA | P17252 | 12/20 | 0.74 |
| ▸ | PRKCE | Q02156 | 9/20 | 0.74 |
| ▸ | GSK3B | P49841 | 5/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | QPCT | Q16769 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840192 | 0.89 | PRKCA (0.76) | PRKCBPRKCAPRKCEGSK3BFLT3 | |
| SCHEMBL14041503 | 0.87 | GSK3B (0.62) | GSK3BKDRFLT3PRKD1TDP1 | |
| SCHEMBL14722002 | 0.85 | PRKCB (0.55) | PRKCBPRKCAPRKCEGSK3BPRKD1 | |
| SCHEMBL7842285 | 0.85 | PRKCB (1.00) | PRKCBPRKCAPRKCEGSK3BJAK2 | |
| SCHEMBL7839690 | 0.85 | JAK2 (0.77) | PRKCBPRKCAPRKCEGSK3BJAK2 | |
| SCHEMBL14041601 | 0.83 | GSK3B (0.66) | PRKCAGSK3BKDRFLT3 | |
| SCHEMBL7842615 | 0.82 | PRKCB (0.94) | PRKCBPRKCAPRKCEGSK3BJAK2 | |
| SCHEMBL9083990 | 0.81 | PRKD1 (0.81) | PRKCBPRKCAPRKCEGSK3BKDR | |
| SCHEMBL9087453 | 0.79 | PRKD1 (0.70) | GSK3BKDRFLT3PRKD1TDP1 | |
| SCHEMBL7838411 | 0.79 | PRKCB (0.80) | PRKCBPRKCAPRKCEGSK3BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | claimed |
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | disclosed |