Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.83 |
| ▸ | POLB | P06746 | 1/20 | 0.83 |
| ▸ | HTR6 | P50406 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KRAS | P01116 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436988 | 0.91 | KDM4E (1.00) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL3196770 | 0.85 | ALDH1A1 (0.73) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL8552151 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL28138965 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL9780083 | 0.81 | HTT (0.69) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL29415611 | 0.81 | ALDH1A1 (0.69) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL1424220 | 0.81 | ALDH1A1 (0.69) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL7844138 | 0.81 | HTT (0.69) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL8998008 | 0.81 | KDM4E (0.72) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL27824370 | 0.81 | ALDH1A1 (0.68) | ALDH1A1HTTTSHRKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115772183-A | Indolylethyl fluoroboric acid derivatives, and preparation method and application thereof | 复旦大学 | 2023-03-10 | — | — | CN | disclosed |
| CN-112430206-B | Preparation method of chiral/racemic 6-substituted indole compound | 上海交通大学 | 2022-03-18 | — | — | CN | disclosed |
| CN-112430206-A | Preparation method of chiral/racemic 6-substituted indole compound | 上海交通大学 | 2021-03-02 | — | — | CN | disclosed |
| US-7745641-B2 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-06-29 | — | — | US | disclosed |
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1880993-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-01-23 | — | — | EP | disclosed |
| EP-0831824-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0831824-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039140-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | NR4A1, NR5A2, PRMT8 | ALDH1A1 3131/4885HTT 1717/4885TSHR 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.