Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852250 | 0.88 | HPGD (0.40) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL7845728 | 0.81 | OPRD1 (0.38) | OPRM1KCNH2 | |
| SCHEMBL4272876 | 0.78 | TP53 (0.35) | MEN1KMT2AKDM4EHPGDHTT | |
| SCHEMBL7849699 | 0.74 | AGTR2 (0.42) | LMNASMN1; SMN2 | |
| SCHEMBL3457612 | 0.72 | ADRA1D (0.37) | NR3C1ADRA1DPOLBNR3C2PGR | |
| SCHEMBL7843938 | 0.70 | ADRA1D (0.55) | ADRA1AADRA1DADRA1BKMT2AKDM4E | |
| SCHEMBL7841676 | 0.70 | ADRA1D (0.46) | NR3C1ADRA1AADRA1DADRA1BNR3C2 | |
| SCHEMBL7845310 | 0.69 | ADRA1D (0.55) | NR3C1ADRA1AADRA1DADRA1BKDM4E | |
| Hydrochloric Acid SCHEMBL8564106 | 0.69 | ADRA1D (0.37) | ADRA1DNR3C2KCNH2 | |
| SCHEMBL7849142 | 0.67 | ADRA1D (0.56) | ADRA1AADRA1DADRA1BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831824-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0831824-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039140-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |