Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.47 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2362545 | 0.82 | CA12 (0.47) | GRM5ADORA3 | |
| SCHEMBL14872141 | 0.79 | LMNA (0.52) | LMNAPTGS2SIRT5ADORA3 | |
| SCHEMBL2271347 | 0.78 | LMNA (0.56) | LMNA | |
| SCHEMBL13063663 | 0.78 | LMNA (0.56) | LMNA | |
| SCHEMBL385370 | 0.77 | LMNA (0.60) | LMNA | |
| SCHEMBL13975284 | 0.76 | TLR8 (0.50) | LMNA | |
| SCHEMBL17290366 | 0.76 | ALDH1A1 (0.49) | LMNA | |
| SCHEMBL28103504 | 0.76 | UBE2N (0.47) | LMNAPTGS2SIRT5GRM5 | |
| SCHEMBL34469872 | 0.76 | NOTUM (0.44) | CHRNB2CHRNB4CHRNA3CHRNA4LMNA | |
| SCHEMBL8167904 | 0.75 | MAPT (0.51) | LMNASIRT5ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150958-A1 | SUBSTITUTED PYRAZOLE CARBOXYLIC ACIDS USED TO COMBAT ANAEMIAS | Bayer Aktiengesellschaft (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046208-A1 | SUBSTITUTED PYRAZOLE CARBOXYLIC ACIDS USED TO COMBAT ANAEMIAS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-08-10 | — | — | WO | disclosed |