Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848868 | 0.91 | SMN1; SMN2 (0.33) | ALDH1A1MAPK1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7838193 | 0.90 | ALDH1A1 (0.41) | ALDH1A1TDP1MAPK1KMT2ALMNA | |
| SCHEMBL7845066 | 0.83 | CYP1A2 (0.36) | ALDH1A1TDP1MAPK1KMT2ALMNA | |
| SCHEMBL7837398 | 0.83 | ALDH1A1 (0.36) | ALDH1A1TDP1MAPK1KMT2ALMNA | |
| SCHEMBL7850479 | 0.81 | NPSR1 (0.36) | ALDH1A1MAPK1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7846307 | 0.80 | PKM (0.39) | ALDH1A1TDP1MAPK1KMT2ALMNA | |
| SCHEMBL7846309 | 0.79 | CYP1A2 (0.40) | ALDH1A1TDP1MAPK1KMT2ALMNA | |
| SCHEMBL7849223 | 0.78 | SLC10A2 (0.35) | ALDH1A1MAPK1KMT2ALMNAMAPT | |
| SCHEMBL7838190 | 0.78 | LMNA (0.41) | ALDH1A1TDP1MAPK1KMT2ALMNA | |
| SCHEMBL7848483 | 0.76 | LMNA (0.37) | ALDH1A1MAPK1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |