Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.34 |
| ▸ | CDC25C | P30307 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850479 | 0.86 | NPSR1 (0.36) | SLC10A2CYP19A1MAPK1ALDH1A1LMNA | |
| SCHEMBL7838193 | 0.82 | ALDH1A1 (0.41) | MAPK1ALDH1A1LMNANPSR1CYP1A2 | |
| SCHEMBL7846879 | 0.80 | CA1 (0.38) | ALDH1A1LMNACYP1A2CYP2C19BAZ1A | |
| SCHEMBL7848483 | 0.80 | LMNA (0.37) | SLC10A2CYP19A1MAPK1ALDH1A1LMNA | |
| SCHEMBL7848540 | 0.79 | TBXA2R (0.37) | ALDH1A1LMNACYP1A2CYP2C19BAZ1A | |
| SCHEMBL7848868 | 0.79 | SMN1; SMN2 (0.33) | SLC10A2MAPK1ALDH1A1LMNANPSR1 | |
| SCHEMBL7846313 | 0.78 | ALDH1A1 (0.39) | MAPK1ALDH1A1LMNANPSR1CYP1A2 | |
| SCHEMBL7837753 | 0.78 | CYP19A1 (0.31) | SLC10A2CYP19A1MAPK1ALDH1A1LMNA | |
| SCHEMBL7838190 | 0.77 | LMNA (0.41) | SLC10A2MAPK1ALDH1A1LMNANPSR1 | |
| SCHEMBL7846307 | 0.77 | PKM (0.39) | MAPK1ALDH1A1LMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |