Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 20/20 | 0.47 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
| ▸ | TACR3 | P29371 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204373 | 0.79 | SLC6A3 (0.39) | — | |
| SCHEMBL8296290 | 0.72 | TACR1 (0.50) | TACR1TACR2TACR3 | |
| SCHEMBL8292833 | 0.70 | TACR1 (0.43) | TACR1TACR2TACR3 | |
| SCHEMBL8558088 | 0.69 | PDE4A (0.39) | TACR1 | |
| SCHEMBL8567221 | 0.69 | TACR1 (0.51) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8559263 | 0.67 | TACR1 (0.64) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8300797 | 0.67 | PDE4A (0.40) | TACR1 | |
| SCHEMBL8300796 | 0.66 | TACR1 (0.59) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8970672 | 0.66 | TACR1 (0.47) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8296291 | 0.65 | TACR1 (0.63) | TACR1TACR2TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003743-A4 | 3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2001-04-11 | — | — | EP | disclosed |
| US-6124319-A | TREATING INFLAMMATORY AND IMMUNOREGULATORY DISORDERS AND DISEASES, INCLUDING ASTHMA AND ALLERGIC DISEASES, AUTOIMMUNE PATHOLOGIES SUCH AS RHEUMATOID ARTHRITIS AND ATHEROSCLEROSIS | MERCK & CO., INC. (US) | 2000-09-26 | — | — | US | disclosed |
| EP-1003743-A1 | 3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1998031364-A1 | 3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 1998-07-23 | — | — | WO | disclosed |