Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6025712 | 0.86 | MAOA (0.40) | HTR2AHTR2CKCNH2PTGS2HSD11B1 | |
| SCHEMBL6026294 | 0.84 | HTR2A (0.42) | HTR2AHTR2CKCNH2PTGS2HSD11B1 | |
| SCHEMBL8562014 | 0.74 | EPHX2 (0.53) | PTGS2AKR1C2AKR1C1AKR1C3EPHX2 | |
| SCHEMBL7084244 | 0.74 | EPHX2 (0.53) | PTGS2AKR1C2AKR1C1AKR1C3EPHX2 | |
| SCHEMBL6025683 | 0.73 | CA1 (0.43) | — | |
| SCHEMBL682581 | 0.72 | CES2 (0.53) | NPC1GAA | |
| SCHEMBL27718384 | 0.70 | CYP3A4 (0.40) | HSD11B1GAA | |
| SCHEMBL8423743 | 0.69 | HTR2A (0.40) | HTR2AHTR2CKCNH2PTGS2HSD11B1 | |
| SCHEMBL2534850 | 0.69 | CES2 (0.48) | NPC1 | |
| SCHEMBL27652206 | 0.69 | L3MBTL1 (0.40) | HTR2AHTR2CKCNH2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |