Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026294 | 0.79 | HTR2A (0.42) | HTR2AHTR2CKCNH2PTGS2HSD11B1 | |
| SCHEMBL8423741 | 0.77 | EPHX2 (0.48) | PTGS2ESR2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL8534192 | 0.76 | PTGS2 (0.41) | PTGS2CYP2D6CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL7846563 | 0.69 | HTR2A (0.39) | HTR2AHTR2CKCNH2PTGS2HSD11B1 | |
| SCHEMBL16316789 | 0.66 | CYP3A4 (0.43) | HTR2AHTR2CKCNH2CYP2D6CYP3A4 | |
| SCHEMBL8388365 | 0.65 | ESR2 (0.44) | PTGS2ESR2HSD11B1MAPT | |
| SCHEMBL28748849 | 0.65 | HTR2A (0.49) | HTR2AHTR2CKCNH2CYP2D6CYP3A4 | |
| SCHEMBL28019207 | 0.64 | CYP3A4 (0.40) | HTR2AHTR2CKCNH2CYP2D6CYP3A4 | |
| SCHEMBL27991976 | 0.64 | LMNA (0.44) | HTR2AHTR2CKCNH2CYP2D6CYP3A4 | |
| SCHEMBL7083981 | 0.63 | MMP1 (0.48) | PTGS2HSD11B1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788476-B1 | STILBENE DERIVATIVES USEFUL AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST CANADA INC (CA) | 1999-10-20 | — | — | EP | claimed |