Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.51 |
| ▸ | RORC | P51449 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843820 | 0.93 | RORC (0.56) | PI4KBRORCMEN1KMT2AALDH1A1 | |
| SCHEMBL7842490 | 0.92 | RORC (0.53) | PI4KBRORC | |
| SCHEMBL7846567 | 0.86 | RORC (0.57) | PI4KBRORCMEN1KMT2AACHE | |
| SCHEMBL7846413 | 0.85 | RORC (0.56) | PI4KBRORCMEN1KMT2AALDH1A1 | |
| SCHEMBL7842696 | 0.84 | MAPT (0.50) | MEN1KMT2AALDH1A1MAPTPTGS2 | |
| SCHEMBL7843454 | 0.81 | MAOB (0.50) | PTGS2 | |
| SCHEMBL7833745 | 0.81 | SMN1; SMN2 (0.56) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7845041 | 0.81 | KMT2A (0.48) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7842483 | 0.80 | SMN1; SMN2 (0.55) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7843818 | 0.79 | RORC (0.68) | PI4KBRORCMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |