Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | RORB | Q92753 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846573 | 0.92 | PI4KB (0.51) | RORCPI4KB | |
| SCHEMBL7843820 | 0.90 | RORC (0.56) | RORCPI4KBRORB | |
| SCHEMBL7842487 | 0.87 | PTGS2 (0.55) | RORCCSNK1DPI4KB | |
| SCHEMBL7842693 | 0.85 | KMT2A (0.50) | — | |
| SCHEMBL7846413 | 0.83 | RORC (0.56) | RORCPI4KBRORB | |
| SCHEMBL7843267 | 0.82 | MAOB (0.48) | — | |
| SCHEMBL7840955 | 0.81 | KMT2A (0.46) | RORC | |
| SCHEMBL7842273 | 0.81 | SMN1; SMN2 (0.52) | — | |
| SCHEMBL7840168 | 0.80 | PTGS2 (0.44) | — | |
| SCHEMBL7844202 | 0.79 | L3MBTL1 (0.44) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |