Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | RORB | Q92753 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846573 | 0.93 | PI4KB (0.51) | RORCPI4KBMEN1ALDH1A1KMT2A | |
| SCHEMBL7846413 | 0.92 | RORC (0.56) | RORCPI4KBADORA2AADORA1MEN1 | |
| SCHEMBL7842490 | 0.90 | RORC (0.53) | RORCPI4KBRORB | |
| SCHEMBL7846410 | 0.86 | RORC (0.68) | RORCPI4KBADORA2AADORA1MEN1 | |
| SCHEMBL7843818 | 0.86 | RORC (0.68) | RORCPI4KBADORA2AADORA1MEN1 | |
| SCHEMBL7842483 | 0.85 | SMN1; SMN2 (0.55) | ADORA2AADORA1MEN1ALDH1A1KMT2A | |
| SCHEMBL7833745 | 0.84 | SMN1; SMN2 (0.56) | ADORA2AADORA1MEN1ALDH1A1KMT2A | |
| SCHEMBL7832959 | 0.82 | PTGS2 (0.54) | PTGS2 | |
| SCHEMBL7845041 | 0.82 | KMT2A (0.48) | ADORA2AADORA1MEN1ALDH1A1KMT2A | |
| SCHEMBL7843112 | 0.81 | SMN1; SMN2 (0.53) | ADORA2AADORA1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |