Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 15/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920400 | 0.86 | ACHE (0.58) | ACHEMAOAMAOBBCHE | |
| SCHEMBL803477 | 0.86 | ACHE (0.58) | ACHEMAOAMAOBBCHE | |
| SCHEMBL784108 | 0.86 | MAOA (0.45) | ACHEDRD3MAOAMAOBBCHE | |
| SCHEMBL876204 | 0.84 | ACHE (0.56) | ACHEDRD3MAOAMAOBBCHE | |
| SCHEMBL484852 | 0.84 | ACHE (0.54) | ACHEDRD3MAOAMAOBALDH1A1 | |
| SCHEMBL878683 | 0.83 | MAOA (0.42) | ACHEDRD3MAOAMAOBBCHE | |
| SCHEMBL484566 | 0.82 | MAOA (0.41) | ACHEDRD3MAOAMAOBBCHE | |
| SCHEMBL13131222 | 0.81 | CA12 (0.51) | ACHEDRD3ALDH1A1 | |
| SCHEMBL10277937 | 0.81 | CA12 (0.51) | ACHEDRD3ALDH1A1 | |
| SCHEMBL784272 | 0.80 | ALDH1A1 (0.45) | ACHEDRD3MAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | ACHE 746/4885DRD3 85/4885MAOA 726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.