Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199298 | 0.79 | ALDH1A1 (0.49) | ESR1HIF1AKMT2ARECQLSMN1; SMN2 | |
| SCHEMBL2748108 | 0.79 | ALDH1A1 (0.40) | HMGCRKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL7140477 | 0.79 | TUBB4A (0.46) | HIF1AKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL7530957 | 0.78 | ACHE (0.52) | HMGCRFGFR1VCPKMT2ASMN1; SMN2 | |
| SCHEMBL27707958 | 0.78 | LMNA (0.45) | HMGCRESR1HIF1AKMT2ARECQL | |
| SCHEMBL15547744 | 0.76 | NFE2L2 (0.47) | FGFR1VCPSMN1; SMN2ALOX15ACHE | |
| SCHEMBL27707747 | 0.76 | MAPT (0.44) | FGFR1VCPESR1HIF1AKMT2A | |
| SCHEMBL9329178 | 0.74 | ALDH1A1 (0.50) | FGFR1VCPKMT2AKDM4EMEN1 | |
| SCHEMBL9024109 | 0.73 | LMNA (0.45) | HMGCRKMT2ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6055987 | 0.73 | ALDH1A1 (0.47) | KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| CN-1046730-C | Pyrazolo [1,5-a ] pyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 1999-11-24 | — | — | CN | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| CN-1131948-A | Pyrazolo [1, 5-a ] pyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 1996-09-25 | — | — | CN | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |