SCHEMBL8726110

SCHEMBL8726110

[CH2]Cc1ccc(N2CCC(NC)CC2)cc1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
USP28 Q96RU2 1/20 0.40
MCHR1 Q99705 1/20 0.40
CYP2D6 P10635 1/20 0.40
CHRM1 P11229 1/20 0.40
HRH1 P35367 1/20 0.40
ME3 Q16798 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
L3MBTL3 Q96JM7 7/20 0.39
L3MBTL1 Q9Y468 7/20 0.39
NCF1 P14598 1/20 0.39
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
MCL1 Q07820 1/20 0.38
MBTD1 Q05BQ5 1/20 0.37
TP53BP1 Q12888 1/20 0.37
HRH4 Q9H3N8 5/20 0.36
KCNH2 Q12809 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8730126 0.87 USP28 (0.43) USP28MCHR1CYP2D6CHRM1HRH1
SCHEMBL8728952 0.84 L3MBTL3 (0.40) USP28MCHR1ME3SMN1; SMN2L3MBTL3
SCHEMBL8729299 0.84 SMN1; SMN2 (0.40) USP28ME3SMN1; SMN2L3MBTL3L3MBTL1
SCHEMBL15372617 0.83 TPSAB1 (0.44) USP28MCHR1CYP2D6CHRM1HRH1
SCHEMBL5250062 0.81 CYP2D6 (0.52) CYP2D6CHRM1HRH1SMN1; SMN2HRH3
SCHEMBL8728954 0.79 ADRB1 (0.50) MCHR1SMN1; SMN2L3MBTL3L3MBTL1NPC1
SCHEMBL3440289 0.79 MAPT (0.55) USP28MCHR1SMN1; SMN2L3MBTL3L3MBTL1
SCHEMBL22837853 0.77 LTA4H (0.41) USP28MCHR1ME3SMN1; SMN2L3MBTL3
SCHEMBL21590255 0.77 NPY5R (0.46) MCHR1L3MBTL3L3MBTL1HRH4HRH3
SCHEMBL785834 0.77 KMT2A (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0624584-B1 Piperazine derivatives useful as calmodulin inhibitors DAIICHI SEIYAKU CO (JP) 1998-08-19 EP disclosed
US-5681954-A HAS CALMODULIN INHIBITORY ACTIVITY; USEFUL IN TREATING DISEASES OF THE CIRCULATORY ORGANS OR IN CEREBRAL REGION DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1997-10-28 US disclosed
EP-0624584-A1 Piperazine derivatives useful as calmodolin inhibitors DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1994-11-17 EP disclosed