Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.53 |
| ▸ | PTPRB | P23467 | 3/20 | 0.53 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.53 |
| ▸ | PTPRC | P08575 | 2/20 | 0.53 |
| ▸ | PTPRE | P23469 | 2/20 | 0.53 |
| ▸ | PTPRA | P18433 | 1/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11494816 | 0.85 | GPR35 (0.61) | GPR35PTPN1PTPN2PTPRBPTPN6 | |
| SCHEMBL17968439 | 0.83 | AKR1C3 (0.48) | GPR35PTPN1AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL25235287 | 0.81 | AKR1B10 (0.49) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL1304624 | 0.81 | NEU3 (0.54) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL7848417 | 0.80 | PTPN1 (0.56) | GPR35PTPN1PTPN2PTPRBPTPN6 | |
| SCHEMBL7847232 | 0.80 | ACLY (0.59) | GPR35PTPN1PTPN2PTPRBPTPN6 | |
| SCHEMBL3896659 | 0.80 | AKR1B10 (0.47) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL7846225 | 0.80 | GRIK1 (0.64) | PTPN1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL3896652 | 0.80 | AKR1B10 (0.47) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL9353927 | 0.79 | AKR1C3 (0.49) | PTPN1AKR1B10AKR1B1AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1080068-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | Novo Nordisk A/S (DK) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999046237-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |