Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.56 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.51 |
| ▸ | PTPRB | P23467 | 3/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.51 |
| ▸ | PTPRC | P08575 | 2/20 | 0.51 |
| ▸ | PTPRE | P23469 | 2/20 | 0.51 |
| ▸ | PTPRA | P18433 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.51 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.43 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836703 | 0.86 | PTPN1 (0.65) | PTPN1PTPN2PTPRBPTPN6PTPRC | |
| SCHEMBL7144739 | 0.82 | KDM4E (0.51) | GRIK1CLCN2KEAP1NPC1KCNK2 | |
| SCHEMBL7848210 | 0.80 | GPR35 (0.58) | PTPN1PTPN2PTPRBPTPN6PTPRC | |
| SCHEMBL9744446 | 0.79 | GRIK1 (0.49) | GRIK1CLCN2KEAP1NPC1 | |
| SCHEMBL9743950 | 0.79 | GRIK1 (0.56) | GRIK1CLCN2KEAP1NPC1KCNK2 | |
| SCHEMBL7847232 | 0.79 | ACLY (0.59) | PTPN1PTPN2PTPRBPTPN6PTPRC | |
| SCHEMBL7846225 | 0.79 | GRIK1 (0.64) | PTPN1GRIK1 | |
| SCHEMBL9743979 | 0.78 | MAPT (0.58) | GRIK1NPC1 | |
| SCHEMBL13885544 | 0.78 | ALDH1A1 (0.51) | GRIK1CLCN2KEAP1 | |
| SCHEMBL12798622 | 0.78 | GRIK1 (0.51) | GRIK1CLCN2KEAP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | claimed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | claimed |
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1080068-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | Novo Nordisk A/S (DK) | 2001-03-07 | — | — | EP | disclosed |
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046237-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |