SCHEMBL7848247

SCHEMBL7848247

FC(F)(F)Oc1ccccc1O[C]1CCCCC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 5/20 0.39
DRD2 P14416 4/20 0.39
RXRA P19793 1/20 0.39
RXRB P28702 1/20 0.39
RXRG P48443 1/20 0.39
ANO1 Q5XXA6 2/20 0.38
SLC6A2 P23975 2/20 0.37
HCRTR1 O43613 1/20 0.35
HCRTR2 O43614 1/20 0.35
ALDH1A1 P00352 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
DDB1 Q16531 2/20 0.35
CRBN Q96SW2 2/20 0.35
OPRM1 P35372 1/20 0.34
S1PR1 P21453 2/20 0.34
NR1I2 O75469 1/20 0.34
HSD11B1 P28845 1/20 0.34
SLC6A4 P31645 1/20 0.33
FFAR1 O14842 1/20 0.33
TRPA1 O75762 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4654446 0.77 RXRA (0.47) SLC6A3RXRARXRBRXRGSLC6A2
SCHEMBL9588707 0.73 CA1 (0.43) RXRARXRBRXRGALDH1A1L3MBTL1
SCHEMBL6284651 0.73 DHODH (0.41) ALDH1A1FFAR1
SCHEMBL5067351 0.70 SLC6A4 (0.32) SLC6A3SLC6A2SLC6A4
SCHEMBL12473634 0.68 ALDH1A1 (0.42) ALDH1A1L3MBTL1S1PR1HSD11B1TRPA1
SCHEMBL8981759 0.68 HTR1B (0.42) ALDH1A1L3MBTL1
SCHEMBL21224620 0.67 ALDH1A1 (0.31) ALDH1A1
SCHEMBL20149678 0.67 GAA (0.38) SLC6A3DRD2RXRARXRBRXRG
SCHEMBL4800503 0.67 RXRA (0.41) SLC6A3RXRARXRBRXRGSLC6A2
SCHEMBL225016 0.67 CA2 (0.50) RXRARXRBRXRGALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115694-A1 SUBSTITUTED N-ALIPHATIC-N-AROMATIC (TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY Monsanto Company (US) 2001-07-18 EP disclosed
WO-2000018723-A1 SUBSTITUTED N-ALIPHATIC-N-AROMATIC TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY MONSANTO COMPANY (US) 2000-04-06 WO disclosed