Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 9/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 1/20 | 0.35 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29104142 | 0.90 | DRD2 (0.51) | DRD2SLC6A4KDM4EALDH1A1RORC | |
| SCHEMBL29104136 | 0.86 | KDM4E (0.39) | DRD2SLC6A4KDM4EALDH1A1RORC | |
| SCHEMBL29104115 | 0.85 | GSK3B (0.43) | DRD2SLC6A4RORCSCN9A | |
| SCHEMBL29104126 | 0.85 | KMT2A (0.39) | DRD2SLC6A4KDM4EALDH1A1HTR1A | |
| SCHEMBL29104149 | 0.82 | MTNR1A (0.43) | — | |
| SCHEMBL6637786 | 0.81 | SLC6A4 (0.50) | SLC6A4RORCHTR1A | |
| SCHEMBL28544938 | 0.81 | LMNA (0.48) | KDM4EALDH1A1EED | |
| SCHEMBL29104121 | 0.78 | SCN9A (0.40) | DRD2SLC6A4KDM4ESCN9A | |
| SCHEMBL6636952 | 0.77 | DRD2 (0.64) | DRD2SLC6A4KDM4EALDH1A1RORC | |
| SCHEMBL29104137 | 0.77 | SCN9A (0.39) | DRD2SLC6A4KDM4EALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117003738-A | Imidazole spiro compound and synthesis method thereof | 湘潭大学 | 2023-11-07 | — | — | CN | claimed |
| CN-117003738-A | Imidazole spiro compound and synthesis method thereof | 湘潭大学 | 2023-11-07 | — | — | CN | disclosed |
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |