Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | F13A1 | P00488 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723577 | 0.81 | LMNA (0.39) | SMN1; SMN2ALDH1A1LMNAMAPTMT-CO2 | |
| SCHEMBL10592850 | 0.75 | KDM4E (0.84) | KDM4EF13A1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8722523 | 0.75 | TSHR (0.40) | ALDH1A1PTGS1HSD17B10 | |
| SCHEMBL667359 | 0.74 | KDM4E (0.65) | KDM4EF13A1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7858 | 0.74 | KDM4E (0.69) | KDM4EF13A1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL667358 | 0.73 | MTNR1A (0.47) | KDM4EF13A1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL14431407 | 0.73 | KDM4E (0.68) | KDM4EF13A1SMN1; SMN2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL31736052 | 0.72 | KDM4E (0.67) | KDM4EF13A1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL10066080 | 0.71 | KDM4E (0.66) | KDM4EF13A1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8721621 | 0.71 | ALDH1A1 (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115704-A1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018734-A1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-04-06 | — | — | WO | disclosed |