Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8692158 | 0.86 | TOP2A (0.44) | TOP2ATOP2BKDM4EKMT2AALDH1A1 | |
| SCHEMBL7016264 | 0.80 | KDM4E (0.51) | TOP2ATOP2BKDM4EKMT2AALDH1A1 | |
| SCHEMBL7840741 | 0.78 | ADRB2 (0.34) | TOP2ATOP2BKMT2AALDH1A1HSD17B10 | |
| SCHEMBL7503528 | 0.77 | ADRB2 (0.40) | TOP2ATOP2B | |
| SCHEMBL7851893 | 0.76 | CYP3A4 (0.31) | CUL4A | |
| SCHEMBL7841811 | 0.73 | TDP1 (0.37) | KMT2AALDH1A1HSD17B10POLBCUL4A | |
| SCHEMBL7840720 | 0.71 | TNF (0.33) | KDM4EKMT2AALDH1A1HSD17B10POLB | |
| SCHEMBL7849137 | 0.69 | KDM4E (0.33) | KDM4EALDH1A1CUL4A | |
| SCHEMBL7849978 | 0.68 | GABRA2 (0.39) | KMT2APOLB | |
| SCHEMBL11200216 | 0.68 | TOP2A (0.49) | TOP2ATOP2BKDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726270-B1 | Derivatives of 1,6-naphthyridone carboxylic acids | BAYER AG (DE) | 2001-05-23 | — | — | EP | disclosed |
| EP-0726270-A1 | Derivatives of 1,6-naphthyridine carboxylic acids | BAYER AG (DE) | 1996-08-14 | — | — | EP | disclosed |