Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | C1R | P00736 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 9/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7851507 | 0.90 | CYP1A2 (0.35) | RXFP1NPC1RAB9AKMT2AC1R | |
| SCHEMBL9510677 | 0.81 | ALOX15 (0.50) | NPC1RAB9AKMT2AMAPTTP53 | |
| SCHEMBL8109553 | 0.80 | ALDH1A1 (0.43) | KMT2AMAPTMEN1ALDH1A1EDNRB | |
| SCHEMBL12794312 | 0.78 | EDNRB (0.39) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2227888 | 0.78 | NPC1 (0.39) | RXFP1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL8177826 | 0.75 | RAB9A (0.47) | RXFP1NPC1RAB9AMAPTTP53 | |
| SCHEMBL8117762 | 0.74 | TDP1 (0.51) | NPC1NOS1KMT2AC1RMAPT | |
| SCHEMBL23176766 | 0.73 | RAB9A (0.59) | RXFP1NPC1RAB9AMAPTTP53 | |
| SCHEMBL7855029 | 0.72 | TDP1 (0.45) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL18955869 | 0.70 | TTR (0.45) | NPC1RAB9AKMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140946-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035919-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-06-22 | — | — | WO | disclosed |