Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838973 | 0.80 | ALDH1A1 (0.39) | POLBALDH1A1TP53KMT2AMAPT | |
| SCHEMBL9311052 | 0.71 | KMT2A (0.47) | ALDH1A1KMT2AMAPTMEN1NPSR1 | |
| SCHEMBL8440219 | 0.71 | NPFFR1 (0.42) | POLBALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL7823070 | 0.71 | RAB9A (0.51) | POLBALDH1A1TP53KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL7839095 | 0.70 | KMT2A (0.46) | ALDH1A1KMT2AMAPTMEN1NPSR1 | |
| SCHEMBL9153197 | 0.69 | NPFFR1 (0.38) | ALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7841180 | 0.66 | CYP1A2 (0.41) | ALDH1A1KMT2AMAPTMEN1NPSR1 | |
| SCHEMBL7853476 | 0.66 | CA2 (0.43) | POLBALDH1A1RAB9ANPC1 | |
| SCHEMBL20335073 | 0.66 | MEN1 (0.61) | POLBALDH1A1TP53KMT2AMAPT | |
| SCHEMBL7251038 | 0.66 | CTRB1 (0.44) | ALDH1A1RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |