Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836633 | 0.82 | TSHR (0.36) | LTA4HMAPTMEN1KMT2AKDM4E | |
| SCHEMBL5173758 | 0.80 | ESR1 (0.42) | LTA4HMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6627059 | 0.80 | ALDH1A1 (0.37) | MAPTTP53MEN1KMT2AKDM4E | |
| SCHEMBL27458021 | 0.76 | MAPT (0.40) | LTA4HMAPTTP53MEN1KMT2A | |
| SCHEMBL4961982 | 0.76 | MCHR1 (0.47) | LTA4HMAPTTP53MEN1KMT2A | |
| SCHEMBL29200144 | 0.74 | ELANE (0.41) | LTA4HMAPTTP53MEN1KMT2A | |
| SCHEMBL7305599 | 0.74 | LTA4H (0.47) | LTA4HMAPTTP53MEN1KMT2A | |
| SCHEMBL4887689 | 0.74 | L3MBTL1 (0.33) | MAPTTP53MEN1KMT2AKDM4E | |
| SCHEMBL29200149 | 0.72 | PTGS2 (0.42) | LTA4HMAPTTP53MEN1KMT2A | |
| SCHEMBL687572 | 0.72 | MAPT (0.39) | LTA4HMAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| CN-1046730-C | Pyrazolo [1,5-a ] pyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 1999-11-24 | — | — | CN | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| CN-1131948-A | Pyrazolo [1, 5-a ] pyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 1996-09-25 | — | — | CN | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |