Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371364 | 0.87 | ESR1 (0.38) | TSHRCYP3A4ALDH1A1L3MBTL1GLA | |
| SCHEMBL8451446 | 0.86 | HSD17B10 (0.41) | TSHRCYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL7849136 | 0.82 | LTA4H (0.38) | CYP3A4ALDH1A1MEN1KMT2AESR1 | |
| SCHEMBL294484 | 0.78 | TSHR (0.44) | TSHRCYP3A4ALDH1A1L3MBTL1GLA | |
| SCHEMBL972325 | 0.74 | ALDH1A1 (0.43) | TSHRALDH1A1L3MBTL1GLAMEN1 | |
| SCHEMBL10884933 | 0.73 | ALDH1A1 (0.48) | TSHRCYP3A4ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL674008 | 0.73 | ALDH1A1 (0.52) | CYP3A4ALDH1A1L3MBTL1GLAMEN1 | |
| SCHEMBL9825698 | 0.73 | ALDH1A1 (0.52) | CYP3A4ALDH1A1L3MBTL1GLAMEN1 | |
| SCHEMBL392541 | 0.72 | LMNA (0.43) | TSHRCYP3A4ALDH1A1KMT2AKDM4E | |
| SCHEMBL31376349 | 0.71 | KDM4E (0.47) | TSHRCYP3A4ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| CN-1046730-C | Pyrazolo [1,5-a ] pyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 1999-11-24 | — | — | CN | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| CN-1131948-A | Pyrazolo [1, 5-a ] pyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 1996-09-25 | — | — | CN | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |