Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30890603 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2TSHRCYP3A4GPR35KDM4E | |
| SCHEMBL761929 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2TSHRCYP3A4GPR35KDM4E | |
| SCHEMBL21596680 | 0.80 | TDP1 (0.44) | SMN1; SMN2TSHRCYP3A4GPR35KDM4E | |
| SCHEMBL30612243 | 0.80 | TDP1 (0.44) | SMN1; SMN2TSHRCYP3A4GPR35KDM4E | |
| SCHEMBL2083152 | 0.78 | ALDH1A1 (0.50) | SMN1; SMN2TSHRCYP3A4GPR35KDM4E | |
| SCHEMBL12161594 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2TSHRCYP3A4GPR35KDM4E | |
| SCHEMBL126405 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2TSHRCYP3A4GPR35KDM4E | |
| SCHEMBL541340 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2TSHRCYP3A4GPR35KDM4E | |
| SCHEMBL2711056 | 0.77 | TSHR (0.41) | TSHRCYP3A4GPR35MAPTTDP1 | |
| SCHEMBL1720997 | 0.77 | TDP1 (0.37) | SMN1; SMN2TSHRCYP3A4KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240199647-A1 | ANTI-VIRAL COMPOUNDS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2024-06-20 | — | — | US | disclosed |
| WO-2024097296-A1 | ANTI-VIRAL COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2024-05-10 | — | — | WO | disclosed |
| EP-3600312-B1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICALS CO (JP) | 2023-05-17 | — | — | EP | disclosed |
| CN-110520127-B | Piperidinyl-substituted and piperazinyl-substituted heteroaromatic carboxamides as modulators of GPR6 | 武田药品工业株式会社 | 2023-05-16 | — | — | CN | disclosed |
| US-11426397-B2 | Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2022-08-30 | — | — | US | disclosed |
| US-11001569-B2 | 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-05-11 | — | — | US | disclosed |
| CN-109311846-B | Novel 6-membered heteroaromatic substituted cyanoindole derivatives as NIK inhibitors | 杨森制药有限公司 | 2021-03-19 | — | — | CN | disclosed |
| US-20200375969-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA CALIFORNIA, INC. | 2020-12-03 | — | — | US | disclosed |
| US-20200109129-A1 | NEW 6-MEMBERED HETEROAROMATIC SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN-CILAG (FR) | 2020-04-09 | — | — | US | disclosed |
| EP-3600312-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2020-02-05 | — | — | EP | disclosed |
| EP-0717743-B1 | N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES | DOW AGROSCIENCES LLC (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-0972774-A2 | 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-pyridines | Dow AgroSciences LLC (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5700940-A | FOR PRE- OR POSTEMERGENCE SPRAYING OF PLANTS OR SOILS | DOWELANCO (US) | 1997-12-23 | — | — | US | disclosed |
| US-5614469-A | N-pyridinyl[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides | DOWELANCO (US) | 1997-03-25 | — | — | US | disclosed |
| US-5571775-A | EFFECTIVE ON A BROAD SPECTRUM OF VEGETATION AT LOW APPLICATION RATES | DOWELANCO (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0717745-A1 | N-PYRIDINYL 1,2,4]TRIAZOLO 1,5-C]PYRIMIDINE-2-SULFONAMIDE HERBICIDES | DOWELANCO (US) | 1996-06-26 | — | — | EP | disclosed |
| EP-0717743-A1 | N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES | DOWELANCO (US) | 1996-06-26 | — | — | EP | disclosed |
| WO-1996001826-A1 | N-ARYL[1,2,4]TRIAZOLO[1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES | DOWELANCO (US) | 1996-01-25 | — | — | WO | disclosed |
| WO-1996001828-A1 | N-PYRIDINYL[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE-2-SULFONAMIDE HERBICIDES | DOWELANCO (US) | 1996-01-25 | — | — | WO | disclosed |
| US-5461161-A | Chemical intermediate is 3-amino-2-hal pyridine | DOWELANCO (US) | 1995-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11426397-B2 | Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of GPR6 | GPR6, GPR3, GPR68 | SMN1; SMN2 2346/4885TSHR 687/4885CYP3A4 1246/4885 |
| US-20200375969-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | GPR6, GPR3, GPR68 | SMN1; SMN2 2346/4885TSHR 687/4885CYP3A4 1246/4885 |
| US-11001569-B2 | 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors | NFKBIA, MAP3K14, IKBKG | SMN1; SMN2 4078/4885TSHR 4112/4885CYP3A4 3245/4885 |
| US-20240199647-A1 | ANTI-VIRAL COMPOUNDS | EIF2AK2, ZC3HAV1, HAVCR2 | SMN1; SMN2 239/4885TSHR 4775/4885CYP3A4 2328/4885 |
| US-20200109129-A1 | NEW 6-MEMBERED HETEROAROMATIC SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | NFKBIA, MAP3K14, IKBKG | SMN1; SMN2 3585/4885TSHR 4129/4885CYP3A4 3331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.