SCHEMBL785142

SCHEMBL785142

COc1cc(C)c(O)c(C)c1C(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.40
HPGD P15428 2/20 0.40
LMNA P02545 1/20 0.40
TP53 P04637 1/20 0.40
ALOX15 P16050 1/20 0.40
CA2 P00918 3/20 0.38
CA1 P00915 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
MAP3K14 Q99558 1/20 0.37
ALOX5 P09917 4/20 0.37
PTGS2 P35354 4/20 0.37
PTGS1 P23219 3/20 0.36
EGFR P00533 1/20 0.36
EPHX2 P34913 1/20 0.34
MAPT P10636 3/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
TDP1 Q9NUW8 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL785005 0.83 TP53 (0.52) CYP3A4HPGDLMNATP53ALOX15
SCHEMBL2741241 0.81 CYP3A4 (0.44) CYP3A4HPGDLMNATP53ALOX15
SCHEMBL24407972 0.77 CYP3A4 (0.47) CYP3A4HPGDLMNATP53ALOX15
SCHEMBL9248531 0.77 CYP2C9 (0.45) CYP3A4LMNATP53ALOX15CA2
SCHEMBL784922 0.77 CYP3A4 (0.44) CYP3A4HPGDLMNATP53ALOX15
SCHEMBL1375037 0.76 CYP3A4 (0.41) CYP3A4HPGDLMNATP53ALOX15
SCHEMBL784959 0.75 CYP2C9 (0.43) CYP3A4HPGDLMNATP53ALOX15
SCHEMBL25634351 0.74 ACHE (0.38) CYP3A4HPGDLMNATP53ALOX15
SCHEMBL2244019 0.74 CYP2C19 (0.52) CYP3A4LMNATP53ALOX15CA2
SCHEMBL785019 0.73 FASN (0.45) CYP3A4HPGDLMNATP53ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9523060-B2 Lubricant oil compositions POLNOX CORPORATION (US) 2016-12-20 US disclosed
US-20150159109-A1 Lubricant Oil Compositions POLNOX CORPORATION 2015-06-11 US disclosed
US-8927472-B2 Lubricant oil compositions POLNOX CORPORATION (US) 2015-01-06 US disclosed
US-8691933-B2 Stabilized polyolefin compositions POLNOX CORPORATION (US) 2014-04-08 US disclosed
US-20140011901-A1 Stabilized Polyolefin Compositions POLNOX CORPORATION (US) 2014-01-09 US disclosed
US-8481670-B2 Stabilized polyolefin compositions POLNOX CORPORATION (US) 2013-07-09 US disclosed
US-20130130955-A1 LUBRICANT OIL COMPOSITIONS POLNOX CORPORATION (US) 2013-05-23 US disclosed
US-20130072586-A1 Stabilized Polyolefin Compositions POLNOX CORPORATION (US) 2013-03-21 US disclosed
US-8252884-B2 Stabilized polyolefin compositions POLNOX CORPORATION (US) 2012-08-28 US disclosed
US-20120071596-A1 STABILIZED POLYOLEFIN COMPOSITIONS POLNOX CORPORATION 2012-03-22 US disclosed
US-7601378-B2 Polymeric antioxidants UNIVERSITY OF MASSACHUSETTS LOWELL (US) 2009-10-13 US disclosed
US-7595074-B2 Polymeric antioxidants UNIVERSITY OF MASSACHUSETTS LOWELL (US) 2009-09-29 US disclosed
US-7507454-B2 Polymeric antioxidants UNIVERSITY OF MASSACHUSETTS LOWELL (US) 2009-03-24 US disclosed
US-20080293856-A1 Stabilized polyolefin compositions POLNOX CORPORATION 2008-11-27 US disclosed
US-20070161522-A1 Lubricant oil compositions POLNOX CORPORATION 2007-07-12 US disclosed
US-20070154430-A1 Polymeric antioxidants MASSACHUSETTS LOWELL, UNIVERSITY OF 2007-07-05 US disclosed
US-20070154608-A1 Antioxidant preservatives to increase the shelf life and palatability of lipid-containing foods and other products containing moieties (e.g., unsaturated carbon-carbon bonds) that can be damaged by free radicals; hydroxy substituted benzene polymers UNIVERSITY OF MASSACHUSETTS LOWELL 2007-07-05 US disclosed
US-20070154720-A1 Polymeric antioxidants CHOLLI ASHOK L 2007-07-05 US disclosed
US-20070149660-A1 Stabilized polyolefin compositions POLNOX CORPORATION 2007-06-28 US disclosed
US-7223432-B2 Polymeric antioxidants University of Massachusettes Lowell (US) 2007-05-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070154430-A1 Polymeric antioxidants GPX4, NQO1, LPO CYP3A4 1868/4885HPGD 240/4885LMNA 1071/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.