Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.34 |
| ▸ | CTBP2 | P56545 | 6/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3426193 | 0.84 | CA2 (0.46) | CES2CES1AKR1B1CA2CAMK2A | |
| SCHEMBL41907 | 0.80 | CES1 (0.58) | CES2CES1AKR1B1CTBP2CYP3A4 | |
| SCHEMBL2732935 | 0.78 | LMNA (0.54) | CES2CES1AKR1B1CA2CAMK2A | |
| Hydrochloric Acid SCHEMBL27862997 | 0.78 | CES1 (0.56) | CES2CES1AKR1B1CTBP2CYP3A4 | |
| Bromide SCHEMBL11497452 | 0.78 | CES1 (0.56) | CES2CES1AKR1B1CTBP2CYP3A4 | |
| SCHEMBL27564061 | 0.78 | CES1 (0.56) | CES2CES1AKR1B1CTBP2CYP3A4 | |
| SCHEMBL238714 | 0.78 | AKR1B1 (0.61) | CES2CES1AKR1B1CA2CAMK2A | |
| SCHEMBL17503650 | 0.78 | CES2 (0.32) | CES2CES1AKR1B1CA2CAMK2A | |
| SCHEMBL83884 | 0.77 | CA2 (0.61) | CA2CAMK2ACTBP2LMNAFNTA | |
| SCHEMBL21381425 | 0.76 | CES1 (0.36) | CES2CES1AKR1B1CA2CAMK2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095015-A2 | SULFONYLAMINO CARBOXYLIC ACID N-ARYLAMIDES AS GUANYLATE CYCLASE ACTIVATORS | Aventis Pharma Deutschland GmbH (DE) | 2001-05-02 | — | — | EP | claimed |
| WO-2000002850-A2 | SULFONYLAMINO CARBOXYLIC ACID N-ARYLAMIDES AS GUANYLATE CYCLASE ACTIVATORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-20 | — | — | WO | claimed |
| EP-1095015-A2 | SULFONYLAMINO CARBOXYLIC ACID N-ARYLAMIDES AS GUANYLATE CYCLASE ACTIVATORS | Aventis Pharma Deutschland GmbH (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002850-A2 | SULFONYLAMINO CARBOXYLIC ACID N-ARYLAMIDES AS GUANYLATE CYCLASE ACTIVATORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-20 | — | — | WO | disclosed |