Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 5/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL784402 | 0.94 | CTSS (0.40) | CTSSTAS1R3TAS1R1TAS1R2WDR5 | |
| SCHEMBL785363 | 0.92 | WDR5 (0.37) | CTSSWDR5F10ROCK2 | |
| SCHEMBL785705 | 0.91 | TAS1R3 (0.41) | CTSSTAS1R3TAS1R1TAS1R2WDR5 | |
| SCHEMBL784715 | 0.89 | F10 (0.40) | CTSSAKT1WDR5F10USP30 | |
| SCHEMBL784714 | 0.89 | TRPV1 (0.42) | TAS1R3TAS1R1AKT1JAK2JAK1 | |
| SCHEMBL783987 | 0.89 | WDR5 (0.40) | CTSSAKT1WDR5F10USP30 | |
| SCHEMBL785714 | 0.88 | TRPV1 (0.38) | CTSSF10JAK2JAK1USP30 | |
| SCHEMBL784059 | 0.88 | RORC (0.39) | CTSSTAS1R3TAS1R1TAS1R2AKT1 | |
| SCHEMBL784649 | 0.87 | TAS1R3 (0.41) | CTSSTAS1R3TAS1R1JAK2JAK1 | |
| SCHEMBL785384 | 0.87 | CTSS (0.40) | CTSSTAS1R3TAS1R1TAS1R2WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | claimed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | claimed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | CTSS 824/4885TAS1R3 202/4885TAS1R1 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.