Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | PTGES | O14684 | 5/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.46 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861325 | 0.86 | L3MBTL1 (0.57) | TDP1LMNAL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL7854550 | 0.85 | PPARG (0.46) | TDP1PTGESALOX5PPARGABCB1 | |
| SCHEMBL9204703 | 0.84 | L3MBTL1 (0.54) | TDP1LMNAL3MBTL1MAPTKDM4E | |
| SCHEMBL8331880 | 0.79 | SMN1; SMN2 (0.50) | TDP1LMNAL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL9199846 | 0.78 | MMP8 (0.45) | TDP1PPARGLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL628126 | 0.77 | KMT2A (0.53) | TDP1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9205212 | 0.77 | ALDH1A1 (0.50) | TDP1LMNAL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL9205464 | 0.77 | L3MBTL1 (0.48) | TDP1PPARGABCB1LMNAL3MBTL1 | |
| SCHEMBL8331884 | 0.77 | SMN1; SMN2 (0.48) | TDP1PTGESALOX5PPARGLMNA | |
| SCHEMBL7323723 | 0.76 | TDP1 (0.56) | TDP1L3MBTL1KDM4EALDH1A1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625969-B1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMA INC (US) | 2001-03-07 | — | — | EP | disclosed |
| US-5407954-A | Serotonin antagonism; treats depression, anxiety, hypertension and migraine headaches | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-04-18 | — | — | US | disclosed |
| EP-0625969-A1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 1994-11-30 | — | — | EP | disclosed |
| WO-1993016051-A1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-19 | — | — | WO | disclosed |
| US-5216008-A | Antidepressant, anxiolytic, hypotensive and also treats migraine headaches | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-01 | — | — | US | disclosed |