Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.43 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843881 | 1.00 | FAP (0.46) | FAPFAAHEPHX1KDM4EMAPK1 | |
| SCHEMBL9564104 | 0.86 | EPHX2 (0.53) | FAPEPHX1KDM4EMAPK1NPC1 | |
| SCHEMBL7853236 | 0.84 | PKM (0.60) | EPHX1KDM4EMAPK1NPC1 | |
| SCHEMBL7852927 | 0.81 | FAP (0.54) | FAPKDM4EMAPK1NPC1RAB9A | |
| SCHEMBL7844672 | 0.80 | HTRA1 (0.52) | DRD4SLC6A12SLC6A13 | |
| SCHEMBL5740768 | 0.80 | ALDH1A1 (0.57) | NPC1RAB9AALDH1A1 | |
| SCHEMBL2476769 | 0.80 | ALDH1A1 (0.57) | NPC1RAB9AALDH1A1 | |
| SCHEMBL31313411 | 0.80 | ALDH1A1 (0.57) | NPC1RAB9AALDH1A1 | |
| SCHEMBL7854610 | 0.78 | METAP2 (0.45) | FAAHEPHX1NPC1RAB9ADRD4 | |
| SCHEMBL7853208 | 0.78 | METAP2 (0.45) | FAAHEPHX1NPC1RAB9ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709373-B1 | PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5965556-A | KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5756763-A | ENZYME INHIBITOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1998-05-26 | — | — | US | disclosed |