Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | DUSP22 | Q9NRW4 | 1/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL7857368 | 0.96 | TDP1 (0.73) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL27791421 | 0.94 | TDP1 (0.70) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL27847794 | 0.94 | TDP1 (0.70) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL27867074 | 0.90 | TDP1 (0.84) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Butadiene SCHEMBL21933110 | 0.90 | TSHR (0.76) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL27929378 | 0.89 | TDP1 (0.63) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL697500 | 0.89 | TDP1 (0.81) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL11666360 | 0.88 | ALDH1A1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL28958542 | 0.84 | TDP1 (0.67) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL3095921 | 0.84 | TDP1 (0.67) | TDP1TSHRSMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9786925-B2 | Fuel cell and fuel cell use gas diffusion electrode | NIPPON STEEL & SUMITOMO METAL CORPORATION (JP) | 2017-10-10 | — | — | US | disclosed |
| EP-1748509-B1 | FUEL CELL AND GAS DIFFUSION ELECTRODE FOR FUEL CELL | NIPPON STEEL & SUMITOMO METAL CORP (JP) | 2017-03-01 | — | — | EP | disclosed |
| US-20070224479-A1 | Fuel Cell and Fuel Cell Use Gas Diffusion Electrode | NIPPON STEEL CORPORATION (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1748509-A1 | FUEL CELL AND GAS DIFFUSION ELECTRODE FOR FUEL CELL | Nippon Steel Corporation (JP) | 2007-01-31 | — | — | EP | disclosed |