SCHEMBL7858657

SCHEMBL7858657

C=Cc1ccc([SiH](OC(=O)CC)OC(=O)CC)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 2/20 0.38
TAS1R1 Q7RTX1 2/20 0.38
ALDH1A1 P00352 1/20 0.37
TDP1 Q9NUW8 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA7 P36544 1/20 0.34
CHRNA4 P43681 1/20 0.34
SLC6A4 P31645 1/20 0.33
TP53 P04637 1/20 0.32
TRPA1 O75762 1/20 0.31
ESR1 P03372 1/20 0.31
RECQL P46063 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HIF1A Q16665 1/20 0.31
ALOX15 P16050 1/20 0.30
FGFR1 P11362 1/20 0.30
VCP P55072 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL706768 0.86 HIF1A (0.38) ALDH1A1ESR1RECQLKMT2ASMN1; SMN2
SCHEMBL7858563 0.81 TP53 (0.39) ALDH1A1TDP1TP53TRPA1KMT2A
SCHEMBL1053845 0.77 ELANE (0.43) ALDH1A1ESR1RECQLKMT2ASMN1; SMN2
SCHEMBL28273781 0.75 ALDH1A1 (0.42) TAS1R3TAS1R1ALDH1A1TDP1CHRNB2
SCHEMBL1143852 0.74 KMT2A (0.58) TAS1R3TAS1R1ALDH1A1CHRNB2CHRNB4
SCHEMBL2772762 0.74 ALDH1A1 (0.41) TAS1R3TAS1R1ALDH1A1TDP1CHRNB2
SCHEMBL2770902 0.73 ALDH1A1 (0.44) TAS1R3TAS1R1ALDH1A1TDP1CHRNB2
SCHEMBL12061030 0.71 MEN1 (0.46) TAS1R3TAS1R1ALDH1A1KMT2AHIF1A
SCHEMBL7864084 0.71 ELANE (0.33) ALDH1A1KMT2ASMN1; SMN2
SCHEMBL8103451 0.70 ALDH1A1 (0.50) TAS1R3TAS1R1ALDH1A1TDP1CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6307081-B1 MACROMONOMER HAS ONE OR MORE SILICON-BONDED HYDROGEN ATOMS AT ONE MOLECULAR CHAIN TERMINAL, AND ONE OR MORE ALIPHATICALLY UNSATURATED SILICON-BONDED ORGANIC GROUPS AT THE OTHER MOLECULAR CHAIN TERMINAL. DOW CORNING SILICONE COMPANY, LTD. (JP) 2001-10-23 US disclosed