Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78168 | 0.84 | L3MBTL1 (0.46) | KDM4EL3MBTL1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL78439 | 0.82 | L3MBTL1 (0.63) | KDM4EL3MBTL1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL78591 | 0.81 | ALDH1A1 (0.51) | KDM4EL3MBTL1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL5282486 | 0.80 | KDM4E (0.53) | KDM4EL3MBTL1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL78505 | 0.80 | KDM4E (0.41) | KDM4EL3MBTL1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8407208 | 0.78 | HRH3 (0.43) | KDM4EL3MBTL1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL78506 | 0.78 | L3MBTL1 (0.44) | KDM4EL3MBTL1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3807523 | 0.78 | RAB9A (0.59) | KDM4ERAB9ASMN1; SMN2LMNANPC1 | |
| SCHEMBL91273 | 0.78 | L3MBTL1 (0.50) | KDM4EL3MBTL1SMN1; SMN2LMNAHRH3 | |
| SCHEMBL1535645 | 0.77 | KDM4E (0.53) | KDM4EL3MBTL1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |