Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 5/20 | 0.48 |
| ▸ | TNFSF11 | O14788 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7859401 | 0.85 | MEN1 (0.60) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7860372 | 0.83 | PLK1 (0.45) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL8715760 | 0.78 | ALDH1A1 (0.52) | LMNAHTR6DRD2HDAC1HDAC2 | |
| SCHEMBL8719842 | 0.74 | HTR6 (0.47) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7853702 | 0.73 | MEN1 (0.45) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7853706 | 0.73 | MEN1 (0.45) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL8998784 | 0.70 | LMNA (0.74) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL948989 | 0.70 | AKR1C3 (0.83) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL27512717 | 0.69 | SRD5A1 (0.52) | — | |
| SCHEMBL4926276 | 0.68 | LMNA (0.74) | PLK1MEN1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753511-B1 | 4-INDOL-1-YL BUTYRIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ALPHA1-ADRENERGIC RECEPTORS AND TESTOSTERONE 5ALPHA-REDUCTASES | ZERIA PHARM CO LTD (JP) | 2001-07-11 | — | — | EP | disclosed |
| CN-1067985-C | Indole derivative and medicine containing the same | ZERIA PHARM CO LTD (JP) | 2001-07-04 | — | — | CN | disclosed |
| CN-1145617-A | Indole derivatives and drugs containing the same | ZERIA PHARM CO LTD (JP) | 1997-03-19 | — | — | CN | disclosed |
| EP-0753511-A1 | INDOLE DERIVATIVE AND MEDICINE CONTAINING THE SAME | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-15 | — | — | EP | disclosed |