Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 3/20 | 0.42 |
| ▸ | TNFSF11 | O14788 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853774 | 0.84 | HTR6 (0.49) | MEN1KMT2A | |
| SCHEMBL7859137 | 0.83 | PLK1 (0.49) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL8716050 | 0.82 | NOD2 (0.49) | ALOX5LMNA | |
| SCHEMBL8717851 | 0.79 | HTR6 (0.42) | MEN1KMT2AALOX5LMNASMN1; SMN2 | |
| SCHEMBL7860934 | 0.78 | CNR1 (0.53) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7853702 | 0.77 | MEN1 (0.45) | PLK1MEN1KMT2AALOX5LMNA | |
| SCHEMBL7853706 | 0.77 | MEN1 (0.45) | PLK1MEN1KMT2AALOX5LMNA | |
| SCHEMBL7859401 | 0.73 | MEN1 (0.60) | PLK1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7860826 | 0.73 | MEN1 (0.46) | PLK1MEN1KMT2AALOX5LMNA | |
| SCHEMBL8717853 | 0.72 | HTR6 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753511-B1 | 4-INDOL-1-YL BUTYRIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ALPHA1-ADRENERGIC RECEPTORS AND TESTOSTERONE 5ALPHA-REDUCTASES | ZERIA PHARM CO LTD (JP) | 2001-07-11 | — | — | EP | disclosed |
| EP-0753511-A1 | INDOLE DERIVATIVE AND MEDICINE CONTAINING THE SAME | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-15 | — | — | EP | disclosed |