Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 8/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL7860365 | 0.96 | ADRA1D (0.48) | ADRA1DADRA1AADRA1BCNR1CNR2 | |
| Potassium Ion SCHEMBL7860358 | 0.96 | ADRA1D (0.48) | ADRA1DADRA1AADRA1BCNR1CNR2 | |
| Potassium Ion SCHEMBL7861531 | 0.96 | ADRA1D (0.48) | ADRA1DADRA1AADRA1BCNR1CNR2 | |
| Potassium Ion SCHEMBL8714241 | 0.96 | ADRA1D (0.46) | ADRA1DADRA1AADRA1B | |
| Potassium Ion SCHEMBL7861538 | 0.93 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BCNR1CNR2 | |
| Potassium Ion SCHEMBL7853726 | 0.92 | ADRA1D (0.49) | ADRA1DADRA1AADRA1B | |
| Potassium Ion SCHEMBL7861447 | 0.92 | ADRA1D (0.49) | ADRA1DADRA1AADRA1B | |
| Potassium Ion SCHEMBL7861443 | 0.92 | ADRA1D (0.49) | ADRA1DADRA1AADRA1B | |
| Potassium Ion SCHEMBL7859464 | 0.91 | ADRA1D (0.48) | ADRA1DADRA1AADRA1B | |
| Potassium Ion SCHEMBL7860833 | 0.90 | ADRA1D (0.48) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753511-B1 | 4-INDOL-1-YL BUTYRIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ALPHA1-ADRENERGIC RECEPTORS AND TESTOSTERONE 5ALPHA-REDUCTASES | ZERIA PHARM CO LTD (JP) | 2001-07-11 | — | — | EP | disclosed |
| US-5760040-A | THERAPEUTIC AGENT FOR PROSTATIC HYPERTROPHY, URINATION DISORDER, ALOPECIA AND ACNE | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-02 | — | — | US | disclosed |
| EP-0753511-A1 | INDOLE DERIVATIVE AND MEDICINE CONTAINING THE SAME | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-15 | — | — | EP | disclosed |