Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 4/20 | 0.54 |
| ▸ | CNR2 | P34972 | 3/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852489 | 0.92 | CNR1 (0.60) | CNR1GPR55CNR2GPR35PTGS2 | |
| SCHEMBL9048316 | 0.87 | FAAH (0.61) | PTGS2CA12CA1CA2CA9 | |
| SCHEMBL7859636 | 0.82 | PTGS2 (0.59) | CNR1GPR55GPR35PTGS2CCNE1 | |
| SCHEMBL7852485 | 0.82 | POLB (0.51) | PTGS2CCNE1CDK2CA12CA1 | |
| SCHEMBL16202074 | 0.79 | CNR1 (0.47) | CNR1GPR55CNR2GPR35CA12 | |
| SCHEMBL14996674 | 0.79 | MAPK13 (0.44) | CNR1GPR55CNR2PTGS2KDM4E | |
| SCHEMBL24572684 | 0.78 | CCNE1 (0.54) | CNR1GPR35CCNE1CDK2KDM4E | |
| SCHEMBL7852486 | 0.78 | PTGS2 (0.57) | PTGS2CCNE1CDK2KDM4EAURKA | |
| SCHEMBL7095866 | 0.78 | KDM4E (0.50) | CNR1GPR55CNR2GPR35PTGS2 | |
| SCHEMBL7858370 | 0.78 | PTGS2 (0.60) | PTGS2CCNE1CDK2AURKAPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947717-B2 | Inhibitors of lethal factor protease | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-24 | — | — | US | disclosed |
| US-7947717-B2 | Inhibitors of lethal factor protease | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | CNR1 3875/4885GPR55 4008/4885CNR2 4146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.