Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.78 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.78 |
| ▸ | HTR1A | P08908 | 15/20 | 0.75 |
| ▸ | DRD2 | P14416 | 15/20 | 0.75 |
| ▸ | HTR2A | P28223 | 5/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280720 | 0.88 | OPRM1 (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL9527241 | 0.87 | OPRM1 (0.78) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7543848 | 0.86 | HTR1A (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7649906 | 0.85 | HTR1A (0.83) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7859795 | 0.84 | OPRM1 (0.74) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL4194997 | 0.84 | HTR1A (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL1122147 | 0.82 | OPRM1 (0.71) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| Fumaric Acid SCHEMBL9764481 | 0.80 | OPRM1 (0.65) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL8914068 | 0.80 | OPRM1 (0.65) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| Maleic Acid SCHEMBL9764477 | 0.80 | OPRM1 (0.65) | OPRM1OPRK1HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476028-B1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2002-11-05 | — | — | US | claimed |
| EP-1037635-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6476028-B1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2002-11-05 | — | — | US | disclosed |
| EP-1037635-A1 | COMPOUNDS AND METHODS | Smithkline Beecham (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999017773-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-04-15 | — | — | WO | disclosed |