Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.50 |
| ▸ | PI4KA | P42356 | 3/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30584024 | 1.00 | ADORA2A (0.50) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30332114 | 0.98 | ADORA2A (0.49) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL786455 | 0.98 | ADORA2A (0.49) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL16714635 | 0.95 | ADORA2A (0.49) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30332447 | 0.92 | LMNA (0.50) | ADORA2AADORA3ADORA1LMNATP53 | |
| SCHEMBL786767 | 0.92 | LMNA (0.50) | ADORA2AADORA3ADORA1LMNATP53 | |
| Diaminooctane SCHEMBL6920367 | 0.88 | FLT3 (0.46) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL29602218 | 0.85 | YTHDC1 (0.49) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30677364 | 0.85 | LMNA (0.48) | ADORA2AADORA3ADORA1LMNATP53 | |
| SCHEMBL11961123 | 0.85 | LMNA (0.48) | ADORA2AADORA3ADORA1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777134-A | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-116425751-B | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-116425751-A | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| EP-2438068-B1 | SUBSTITUTED 6-(2-HYDROXYBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THESE DERIVATIVES | Univerzita Palackého v Olomouci (CZ) | 2017-03-01 | — | — | EP | disclosed |
| US-9023857-B2 | Substituted 6-(2-aminobenzylamino)purine derivatives, their use as medicaments and preparations containing these compounds | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2015-05-05 | — | — | US | disclosed |
| EP-2391626-B1 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | Univerzita Palackého v Olomouci (CZ) | 2014-10-01 | — | — | EP | disclosed |
| US-8492391-B2 | Substituted 6-(2-hydroxybenzylamino)purine derivatives, their use as medicaments and compositions containing these derivatives | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2013-07-23 | — | — | US | disclosed |
| EP-2438068-A1 | SUBSTITUTED 6-(2-HYDROXYBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THESE DERIVATIVES | Univerzita Palackého v Olomouci (CZ) | 2012-04-11 | — | — | EP | disclosed |
| US-20120070512-A1 | Substituted 6-(2-hydroxybenzylamino)purine Derivatives, Their Use as Medicaments and Compositions Containing These Derivatives | BIOPATTERNS, S.R.O (CZ) | 2012-03-22 | — | — | US | disclosed |
| EP-2391626-A2 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | Univerzita Palackého v Olomouci (CZ) | 2011-12-07 | — | — | EP | disclosed |
| US-20080214541-A1 | COMPOSITIONS AND METHODS FOR INDUCING OSTEOGENESIS | IRM LLC (BM) | 2008-09-04 | — | — | US | disclosed |
| US-20080214541-A1 | COMPOSITIONS AND METHODS FOR INDUCING OSTEOGENESIS | IRM LLC (BM) | 2008-09-04 | — | — | US | disclosed |
| US-7273864-B2 | Compositions and methods for inducing osteogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-09-25 | — | — | US | disclosed |
| US-7273864-B2 | Compositions and methods for inducing osteogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-09-25 | — | — | US | disclosed |
| US-7273864-B2 | Compositions and methods for inducing osteogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-09-25 | — | — | US | disclosed |
| EP-1556129-A2 | COMPOSITIONS AND METHODS FOR INDUCING OSTEOGENESIS | IRM LLC (BM) | 2005-07-27 | — | — | EP | disclosed |
| US-20040157864-A1 | Compositions and methods for inducing osteogenesis | IRM LLC (BM) | 2004-08-12 | — | — | US | disclosed |
| WO-2004035132-A2 | COMPOSITIONS AND METHODS FOR INDUCING OSTEOGENESIS | IRM LLC (BM) | 2004-04-29 | — | — | WO | disclosed |
| US-4201860-A | BRONCHODILATORS | BRISTOL-MYERS COMPANY (US) | 1980-05-06 | — | — | US | disclosed |
| US-4172829-A | 2,9-Disubstituted adenine derivatives and their use as non-adrenergic bronchodilators | BRISTOL-MYERS COMPANY (US) | 1979-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157864-A1 | Compositions and methods for inducing osteogenesis | BMP2, BMP4, BMP6 | ADORA2A 2423/4885PI4KA 1938/4885PI4K2B 1909/4885 |
| US-20080214541-A1 | COMPOSITIONS AND METHODS FOR INDUCING OSTEOGENESIS | BMP2, BMP4, BMP6 | ADORA2A 2423/4885PI4KA 1938/4885PI4K2B 1909/4885 |
| US-20120070512-A1 | Substituted 6-(2-hydroxybenzylamino)purine Derivatives, Their Use as Medicaments and Compositions Containing These Derivatives | CDK6, CCNI, CDK2 | ADORA2A 95/4885PI4KA 586/4885PI4K2B 528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.