Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715762 | 0.83 | HTR6 (0.50) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL8716050 | 0.80 | NOD2 (0.49) | PPARGPPARAHDAC3HDAC4HDAC1 | |
| SCHEMBL8716053 | 0.77 | ATM (0.40) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL27840261 | 0.75 | MTNR1B (0.48) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL17927650 | 0.74 | HTR6 (0.45) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL7860372 | 0.72 | PLK1 (0.45) | — | |
| SCHEMBL8717851 | 0.71 | HTR6 (0.42) | HTR6HTR1ADRD2HTR7DRD3 | |
| SCHEMBL8715760 | 0.68 | ALDH1A1 (0.52) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL7065141 | 0.68 | HDAC3 (0.67) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL7066115 | 0.67 | BCL2 (0.56) | HTR6HTR1ADRD2HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760040-A | THERAPEUTIC AGENT FOR PROSTATIC HYPERTROPHY, URINATION DISORDER, ALOPECIA AND ACNE | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-02 | — | — | US | disclosed |