Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | ATP4A | P20648 | 1/20 | 0.32 |
| ▸ | ATP4B | P51164 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862260 | 0.90 | CYP19A1 (0.34) | NPC1RAB9AHSD17B10CYP19A1CYP11B1 | |
| SCHEMBL7861310 | 0.85 | MAPT (0.44) | CYP19A1CYP11B1CYP11B2HTR1AADRA1D | |
| SCHEMBL7860116 | 0.81 | EZH2 (0.36) | NPC1RAB9AHTR1AADRA1DADRA1A | |
| SCHEMBL7859923 | 0.79 | CYP19A1 (0.36) | NPC1RAB9ACYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7861125 | 0.78 | MEN1 (0.39) | NPC1RAB9AHTR1AADRA1DADRA1A | |
| SCHEMBL9445181 | 0.74 | KDR (0.38) | — | |
| SCHEMBL7859944 | 0.72 | HTR1A (0.41) | NPC1RAB9AHTR1ALTA4HMAPK14 | |
| SCHEMBL7854338 | 0.71 | HTR1A (0.36) | RAB9AHTR1ALTA4HMAPK14 | |
| SCHEMBL7861309 | 0.70 | HTR6 (0.40) | NPC1RAB9AALDH1A1 | |
| SCHEMBL7859925 | 0.70 | HTR1A (0.46) | HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625969-B1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMA INC (US) | 2001-03-07 | — | — | EP | claimed |
| EP-0625969-B1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMA INC (US) | 2001-03-07 | — | — | EP | disclosed |