Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861001 | 0.81 | NPC1 (0.35) | ALDH1A1NPC1HTR1AADRA1DADRA1A | |
| SCHEMBL9445181 | 0.81 | KDR (0.38) | MAPTL3MBTL1 | |
| SCHEMBL7861310 | 0.77 | MAPT (0.44) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7861125 | 0.75 | MEN1 (0.39) | ALDH1A1NPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7859944 | 0.72 | HTR1A (0.41) | ALDH1A1NPC1ABCB1KDM4EMEN1 | |
| SCHEMBL7862260 | 0.71 | CYP19A1 (0.34) | ALDH1A1NPC1LIPERAB9A | |
| SCHEMBL7859937 | 0.71 | LMNA (0.40) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL9252950 | 0.71 | CHRNB2 (0.40) | ALDH1A1NPC1KDM4EMEN1TP53 | |
| SCHEMBL7859925 | 0.70 | HTR1A (0.46) | ALDH1A1ABCB1KDM4EMEN1TP53 | |
| SCHEMBL7854567 | 0.70 | MTNR1A (0.44) | NPC1ABCB1HTR1ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625969-B1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMA INC (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1993016051-A1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-19 | — | — | WO | claimed |
| US-5216008-A | Antidepressant, anxiolytic, hypotensive and also treats migraine headaches | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-01 | — | — | US | claimed |
| EP-0625969-B1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMA INC (US) | 2001-03-07 | — | — | EP | disclosed |
| US-5407954-A | Serotonin antagonism; treats depression, anxiety, hypertension and migraine headaches | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-04-18 | — | — | US | disclosed |
| US-5216008-A | Antidepressant, anxiolytic, hypotensive and also treats migraine headaches | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-01 | — | — | US | disclosed |