Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863630 | 0.79 | CCR2 (0.36) | CCR2KCNH2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL29430705 | 0.76 | NMT1 (0.49) | CCR2NMT1AKR1B1CA1CA2 | |
| SCHEMBL1581645 | 0.76 | NMT1 (0.49) | CCR2NMT1AKR1B1CA1CA2 | |
| SCHEMBL11993144 | 0.73 | CCR2 (0.41) | CCR2KCNH2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7861158 | 0.71 | HDAC4 (0.42) | — | |
| SCHEMBL6513419 | 0.70 | ALDH1A1 (0.44) | KCNH2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7448176 | 0.70 | ALDH1A1 (0.44) | KCNH2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21164275 | 0.69 | CCR2 (0.38) | CCR2KCNH2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL26999435 | 0.69 | ALDH1A1 (0.54) | — | |
| SCHEMBL48662 | 0.69 | PIK3CD (0.39) | CCR2KCNH2PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086097-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER INC. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064415-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-12-16 | — | — | WO | disclosed |