Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7859899 | 0.84 | ESR1 (0.59) | LMNAPTGS1SLC6A2CYP2C19PTGS2 | |
| SCHEMBL1840533 | 0.82 | TSHR (0.75) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL1461571 | 0.80 | ALDH1A1 (0.48) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| Hydroquinone SCHEMBL51561 | 0.80 | TSHR (0.79) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL7861391 | 0.78 | LTA4H (0.58) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Hydroquinone SCHEMBL7511716 | 0.78 | TSHR (0.75) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL1837574 | 0.77 | ESR1 (0.54) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL6744772 | 0.77 | ESR1 (0.54) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| Phenol SCHEMBL5486172 | 0.75 | TSHR (0.79) | TSHRLMNACYP1A2PTGS1SLC6A2 | |
| Phenol SCHEMBL21518644 | 0.75 | TSHR (0.79) | TSHRLMNACYP1A2PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070084-A4 | PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPase) | ONTOGEN CORP (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1070084-A1 | PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPase) | Ontogen Corporation (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6107274-A | ENZYME INHIBITORS AS HYPOGLYCEMIC AGENTS IN TREATMENT OF TYPE-II DIABETES | ONTOGEN CORPORATION (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1999047549-A1 | PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPase) | ONTOGEN CORPORATION (US) | 1999-09-23 | — | — | WO | disclosed |