Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.57 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12392016 | 0.82 | LMNA (0.58) | LTA4HEPHX2FFAR1FFAR4BCHE | |
| SCHEMBL1461571 | 0.81 | ALDH1A1 (0.48) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL2023885 | 0.80 | LTA4H (0.64) | LTA4HEPHX2FFAR1FFAR4BCHE | |
| SCHEMBL10609652 | 0.79 | LMNA (0.75) | LTA4HEPHX2FFAR1FFAR4BCHE | |
| SCHEMBL339813 | 0.79 | LMNA (0.82) | LTA4HEPHX2BCHELMNACYP1A2 | |
| SCHEMBL12040562 | 0.78 | LTA4H (0.77) | LTA4HEPHX2FFAR1FFAR4BCHE | |
| SCHEMBL5599 | 0.78 | LTA4H (0.66) | LTA4HEPHX2FFAR1FFAR4BCHE | |
| SCHEMBL12630258 | 0.78 | LTA4H (0.77) | LTA4HEPHX2FFAR1FFAR4BCHE | |
| SCHEMBL7861390 | 0.78 | TSHR (0.50) | BCHELMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL1699213 | 0.77 | LTA4H (0.64) | LTA4HEPHX2FFAR1FFAR4BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070084-A4 | PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPase) | ONTOGEN CORP (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1070084-A1 | PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPase) | Ontogen Corporation (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6107274-A | ENZYME INHIBITORS AS HYPOGLYCEMIC AGENTS IN TREATMENT OF TYPE-II DIABETES | ONTOGEN CORPORATION (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1999047549-A1 | PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPase) | ONTOGEN CORPORATION (US) | 1999-09-23 | — | — | WO | disclosed |