SCHEMBL7861699

SCHEMBL7861699

N#Cc1c(F)c(F)c(Oc2c(Cl)cccc2Cl)c(F)c1C#N

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.36
ALDH1A1 P00352 4/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CYP1A2 P05177 2/20 0.36
CYP3A4 P08684 2/20 0.36
CYP2D6 P10635 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
HTR1A P08908 2/20 0.33
SLC6A2 P23975 2/20 0.33
DYRK1A Q13627 2/20 0.33
PSMB8 P28062 1/20 0.33
KMT2A Q03164 3/20 0.33
TLR8 Q9NR97 1/20 0.32
MAPT P10636 4/20 0.32
POLB P06746 1/20 0.32
HSP90AA1 P07900 1/20 0.32
MEN1 O00255 2/20 0.32
GAA P10253 2/20 0.31
GLA P06280 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7868377 0.83 MAPT (0.43) KDM4EALDH1A1HTR1ASLC6A2KMT2A
SCHEMBL3619566 0.81 TRPV4 (0.31)
SCHEMBL6550807 0.81 KDM4E (0.37) KDM4EALDH1A1L3MBTL1CYP1A2CYP3A4
SCHEMBL4594106 0.80 MEN1 (0.36) ALDH1A1CYP3A4KMT2AMAPTMEN1
SCHEMBL7870097 0.79 AR (0.42) KDM4EALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL13439997 0.79 TRPV4 (0.30)
SCHEMBL4594009 0.78 ALDH1A1 (0.34) ALDH1A1CYP3A4KMT2AMAPTMEN1
SCHEMBL7870109 0.77 AR (0.45) KDM4EALDH1A1CYP2C9MAPTPOLB
SCHEMBL7873493 0.76 L3MBTL1 (0.42) KDM4EALDH1A1L3MBTL1CYP1A2CYP3A4
SCHEMBL9618395 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882768-B1 Method for producing of phthalocyanine compound NIPPON CATALYTIC CHEM IND (JP) 2001-12-19 EP disclosed
US-6034236-A REACTING A PHTHALONITRILE WITH A METAL OXIDE IN PRESENCE OF A SULFONIC ACID CATALYST NIPPON SHOKUBAI CO., LTD. (JP) 2000-03-07 US disclosed
EP-0882768-A2 Method for producing of phthalocyanine compound NIPPON SHOKUBAI CO., LTD. (JP) 1998-12-09 EP disclosed