Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 6/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861749 | 0.89 | HDAC1 (0.41) | HDAC1NAMPTAKR1C3AKR1C2NR3C2 | |
| SCHEMBL8205928 | 0.83 | NAMPT (0.39) | HDAC1NAMPTFFAR4PLA2G2A | |
| SCHEMBL7673796 | 0.82 | SLC6A4 (0.43) | NAMPTPTPN1 | |
| SCHEMBL7673802 | 0.82 | SLC6A4 (0.43) | NAMPTPTPN1 | |
| SCHEMBL7856401 | 0.79 | ALPL (0.39) | HDAC1NAMPTFFAR4MAPTPTPN1 | |
| SCHEMBL7665829 | 0.77 | TBXAS1 (0.47) | PLA2G2A | |
| SCHEMBL7665834 | 0.77 | TBXAS1 (0.47) | PLA2G2A | |
| SCHEMBL7863041 | 0.72 | PTGS2 (0.33) | FFAR4HSP90AA1MAPTPTPN1PTGS2 | |
| SCHEMBL7668332 | 0.71 | BCL2L1 (0.38) | NAMPT | |
| SCHEMBL7668328 | 0.71 | BCL2L1 (0.38) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140858-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039716-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |