Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861740 | 0.89 | HDAC1 (0.40) | HDAC1AKR1C3AKR1C2NAMPTNR3C2 | |
| SCHEMBL8204858 | 0.82 | GAA (0.36) | HDAC1BRS3KDM5AKDM4CKDM5B | |
| SCHEMBL7668328 | 0.81 | BCL2L1 (0.38) | BRS3NAMPTHTR2B | |
| SCHEMBL7668332 | 0.81 | BCL2L1 (0.38) | BRS3NAMPTHTR2B | |
| SCHEMBL7866874 | 0.77 | KMO (0.39) | KDM5AKDM4CKDM5BNAMPT | |
| SCHEMBL7669536 | 0.75 | TBXAS1 (0.56) | — | |
| SCHEMBL7564437 | 0.74 | BRS3 (0.36) | BRS3KDM5AKDM4CKDM5BNAMPT | |
| SCHEMBL7673796 | 0.71 | SLC6A4 (0.43) | NAMPTHTR2BSMN1; SMN2 | |
| SCHEMBL7673802 | 0.71 | SLC6A4 (0.43) | NAMPTHTR2BSMN1; SMN2 | |
| SCHEMBL8205928 | 0.71 | NAMPT (0.39) | HDAC1NAMPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140858-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039716-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |