Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204858 | 0.89 | GAA (0.36) | NAMPTGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8212307 | 0.83 | ALDH1A1 (0.47) | NAMPTGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7861740 | 0.83 | HDAC1 (0.40) | NAMPTHDAC1FFAR4PLA2G2A | |
| SCHEMBL8209847 | 0.82 | FNTA (0.41) | ALDH1A1 | |
| SCHEMBL8205732 | 0.81 | FNTA (0.37) | NAMPTGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8273539 | 0.81 | GAA (0.43) | NAMPTGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7241235 | 0.77 | CYP19A1 (0.46) | KDM4E | |
| SCHEMBL8205834 | 0.74 | GAA (0.42) | NAMPTGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8213603 | 0.73 | HTR2B (0.40) | NAMPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7241172 | 0.73 | CCR6 (0.53) | GAAALDH1A1HTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |